Venturoli, S.; Colombo, F.M. Jayaprakasan, K.; Chan, Y.Y. and A.D.S.S. All articles published by MDPI are made immediately available worldwide under an open access license. "Uterine Septum with or without Hysteroscopic Metroplasty: Impact on Fertility and Obstetrical OutcomesA Systematic Review and Meta-Analysis of Observational Research" Journal of Clinical Medicine 11, no. Epub 2006 Jul 12. A, Congenital uterine anomalies (CUAs) are estimated to affect 1% to 4% of the general fertile population [, The definition of uterine septum is still a subject of debate. ; Kapiteijn, K.; et al. ; et al. Carrera, M.; Prez Millan, F.; Alczar, J.L. This trend was confirmed also in the case of PR and PL in general analysis. Platinum-Based Neoadjuvant Chemotherapy versus Primary Surgery in Ovarian Carcinoma International Federation of Gynecology and Obstetrics Stages IIIc and IV: A Systematic Review and Meta-Analysis. The full text of these potentially eligible studies was retrieved and independently assessed for eligibility by other two review team members (MN, GB). Gundabattula, S.R. Visit our dedicated information section to learn more about MDPI. Latest developments and techniques in gynaecological oncology surgery. independently judged the methodological quality of the studies included in the meta-analysis. Objective: we performed a systematic review/meta-analysis to evaluate the impact of septate uterus and hysteroscopic metroplasty on pregnancy rate-(PR), live birth rate-(LBR), spontaneous abortion-(SA) and preterm labor (PL) in infertile/recurrent miscarriage-(RM) patients. Moiad is actively involved in research. This data was not confirmed in the subgroup analysis (infertile versus recurrent miscarriage). In case of a newly diagnosed uterine septum in patients seeking pregnancy without a prior history of reproductive failure, any advantages from septum removal cannot be established due to a lack of clinical scientific data. ; Leone, S.; Maneschi, F. Hysteroscopic treatment of uterine septum. Unfortunately, no data could be extracted about the role of the uterine sub-septum length even if we found no statistically significative differences of PR, LBR, spontaneous abortion and preterm delivery comparing patients with uterine septum versus sub-septum. This study investigates the specific morbidity of rectosigmoid resection (RSR) during Visceral-Peritoneal Debulking (VPD) in a consecutive series of patients with stage IIIC-IV ovarian cancer and compares the results of the colo-rectal vs. the gynaecologic oncology team. Copyrights and related rights for article metadata waived via CC0 1.0 Universal (CC0) Public Domain Dedication. Find out more about the facilities available at KIMS Hospital. The outcome of singleton pregnancies after IVF/ICSI in women before and after hysteroscopic resection of a uterine septum compared to normal controls. 2022. using metafor package for R software, version 4.0 (R Foundation for Statistical Computing, Vienna, Austria) [. Bethesda, MD 20894, Web Policies Sensitivity analyses including only medium and high-quality studies was also performed. 2009;114:2631. The most recent revision of a before/after design studies dates from the year 2000 and is in agreement with our data [, The total complication rate reported ranged between 1.5% and 1.8%. Guarino, S.; Incandela, S.; Maneschi, M.; Vegna, G.; DAnna, M.R. document.getElementById("ak_js_2").setAttribute("value",(new Date()).getTime()); Consultant Gynaecologist / Urogynaecologist, Gynaecologist, Menopause & HRT (BMS accredited specialist). ; Baandrup, U.; Dybkr, K.; Blaakr, J.; Uldbjerg, N.; Srensen, S. Human Papillomavirus Infection as a Possible Cause of Spontaneous Abortion and Spontaneous Preterm Delivery. Finally, the present meta-analysis is also limited by including predominantly observational studies. Please find service updates and current visiting rules in our COVID-19 section. ; Spinder, T.; Kuchenbecker, W.; Jansen, F.W. ; Cahill, A.G. Congenital uterine anomalies and adverse pregnancy outcomes. -, Rafii A, Stoeckle E, Jean-Laurent M, Ferron G, Morice P, Houvenaeghel G, et al. Prevalence and reproductive implications. Dr. Robert J. Tozzi was once again honored with this peer-nominated and physician-researched award, selected as a Castle Connolly Top Doctor as included in the New York Magazine roll-call of Top Doctors 2016. on (201) Family Magazine Names Dr. Robert J. Tozzi One of NY-Metro Areas Top Family Doctors, 2016, on Gregory M. Hirsch Heart Foundation: Evening from the Heart, May 13, 2015, on Dr. Robert J. Tozzi Cited as Castle Connolly 2016 Top Doctor, New York-Metro Area, on Tenafly Students Offered Screenings for Deadly Heart Abnormality, Northjersey.com, 15 February 2016, on Dr. Robert Tozzi Recognized Among Castle Connolly Top Doctors New York Metro Area 2015, on Dr. Robert J. Tozzi Ranked Among New York Magazines Best Doctors 2015, on Dr. Robert J. Tozzi Receives Vitals Patient Choice Award for 2014, on Robert J. Tozzi Recognized as a Top Doctor by Worldwide Registry, on Dr. Robert J. Tozzi Garners Major Kudos as Top Doctor for 2014, on 19-Year-Old Male Athlete With Bicuspid Aortic Valve and Athletic Heart Needing Clearance Prior to Professional Soccer Tryout, on Robert J. Tozzi, Tragedy on the Football Field, WPIX-TV News, NY, 2 September 2014, Dr. Robert J. Tozzi, New York Magazines Best Doctors 2016, New York Magazine, 13 December 2016, (201) Family Magazine Names Dr. Robert J. Tozzi One of NY-Metro Areas Top Family Doctors, 2016, Gregory M. Hirsch Heart Foundation: Evening from the Heart, May 13, 2015, Dr. Robert J. Tozzi Cited as Castle Connolly 2016 Top Doctor, New York-Metro Area, Tenafly Students Offered Screenings for Deadly Heart Abnormality, Northjersey.com, 15 February 2016, Dr. Robert Tozzi Recognized Among Castle Connolly Top Doctors New York Metro Area 2015, Dr. Robert J. Tozzi Ranked Among New York Magazines Best Doctors 2015, Dr. Robert J. Tozzi Receives Vitals Patient Choice Award for 2014, Robert J. Tozzi Recognized as a Top Doctor by Worldwide Registry, Dr. Robert J. Tozzi Garners Major Kudos as Top Doctor for 2014, 19-Year-Old Male Athlete With Bicuspid Aortic Valve and Athletic Heart Needing Clearance Prior to Professional Soccer Tryout, Robert J. Tozzi, Tragedy on the Football Field, WPIX-TV News, NY, 2 September 2014. 2009 Dec;19 Suppl 2:S18-20. and R.T. All authors have read and agreed to the published version of the manuscript. A literature search of relevant papers was conducted using the electronic bibliographic databases (Medline, Scopus, Embase, Science direct, Cochrane library, Clinicaltrials.gov, Cochrane Central Register of Controlled Trials, EU Clinical Trials Register and World Health Organization International Clinical Trials Registry Platform). and transmitted securely. In conclusion, there is broad consensus on the importance of TVUS and the need for further investigation based on risk factors of EC.Keywords: transvaginal ultrasound, endometrial thickness, postmenopausal bleeding, tamoxifen, hormone-replacement therapy. All pre-operative information and surgical details were compared to The inclusion criteria applied in this meta-analysis were the following: Type of study: Case-control studies, cohort studies or case series. Design Prospective pilot study. He has a special interest in developing new surgical techniques in ultra-radical surgery for advanced ovarian cancer and radical pelvic exenteration operations. Septum resection in women with a septate uterus: A cohort study. The aim is to provide a snapshot of some of the Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. She is the Principal Investigator for several national and international clinical trials including ovarian, endometrial and advanced cervical cancers. WebOfficial information from NHS about Churchill Hospital including contact details, directions, opening hours and service/treatment details Any disagreement over the eligibility of a study was resolved through discussion with a third external collaborator (AV). Federal government websites often end in .gov or .mil. The role of HOX genes in human implantation. Practice Committee of the American Society for Reproductive Medicine. (Apr 2022), Carlo Saccardi, Giulia Spagnol, Giulio Bonaldo, Matteo Marchetti, Roberto Tozzi, Marco Noventa Department of Women and Childrens Health, University of Padua, Padua, ItalyCorrespondence: Giulia Spagnol, Obstetrics and Gynecology Clinic, Department of Women and Childrens Health, University of Padua, 3 Via Giustiniani, Padua 35128, Italy, Tel +39 347 359-8173, Email [emailprotected]: Transvaginal ultrasound (TVUS) represents an accurate and noninvasive technique to investigate endometrial thickness (ET) in the early diagnosis of endometrial cancer (EC). Journal of Clinical Medicine. In three studies reporting data from infertile patients, LBR was not different in women with septate uterus vs. controls (OR 2.03, 95% CI 0.42 to 9.73; In six studies reporting data from recurrent abortion, LBR was not different in women who had the uterine septum removed vs. not removed (OR 2.96, 95% CI 0.96 to 9.15; In seven studies with medium/high quality, LBR was higher in women who had the septum removed vs. not removed (OR 3.87, 95% CI 1.47 to 10.20; SA during the first and second trimesters was investigated in nine studies [. 1. No special Photos used throughout the site by David Jorre, Jean-Philippe Delberghe, JJ Ying, Luca Bravo, Brandi Redd, & Christian Perner from Unsplash. Minimal-access surgery has evolved to include any operation by laparoscopy. Help us to further improve by taking part in this short 5 minute survey, Modernizing Total Hip Arthroplasty Perioperative Pathways: The Implementation of ERAS-Outpatient Protocol, Biomarkers in Primary Focal Segmental Glomerulosclerosis in Optimal Diagnostic-Therapeutic Strategy, https://www.mdpi.com/article/10.3390/jcm11123290/s1, https://creativecommons.org/licenses/by/4.0/. WebAdd your review of Mr Roberto Tozzi Share your experience to help others. WebORCID record for Moiad Alazzam. Section with a pair of endoscopic scissors in three cases (4.8%). official website and that any information you provide is encrypted Clipboard, Search History, and several other advanced features are temporarily unavailable. ; validation, A.V., C.S., A.S.L. Infertile: the inability to conceive after 12 months, 27-Fr hysteroresectoscope (Olympus, Hangzhou City, Japan), The resection was performed between the anterior and posterior uterine walls, extending up to the fundus rather than into the fundal myometrium from the lower margin of the septum, Presence of endocrine disease, uterine myoma, adnexal disease. Xiao Y, Xie S, Zhang N, Wang J, Lv C, Guo J, Yang Q. Gynecol Obstet Invest. Concerning uterine perforation, it is interesting to underline that of the 25 cases, 10 cases were reported by one study [, The definitive explanation for the correlation between the septate uterus and impaired reproductive potential is still unclear, although several biological mechanisms have been hypothesized. Ludwin, A.; Martins, W.P. He is widely published and frequently invited to speak at national and international meetings. Women with uterine septum that underwent IVF or ICSI and had a singleton pregnancy (fetal heart activity by ultrasound demonstration), Women without uterine anomalies with a singleton pregnancy after IVF or ICSI. Epub 2017 Dec 21. Lymph node-positive stage IIIC ovarian cancer: a separate entity? Jankowska-Lombarska M, Grabowska-Derlatka L, Derlatka P. Curr Oncol. Based on the most important studies in the literature, we summarized that in premenopausal woman with abnormal uterine bleeding, an optimal cutoff for ET has not yet been established. ; investigation, A.A. and S.G.V. The .gov means its official. Pelvic lesions, such as endometriosisoligo or anovulation and menstrual irregularities; partners with abnormal semen analysis. The team meets every Monday to discuss, in confidence, newly referred patients with a suspected or confirmed diagnosis of a gynaecological cancer. sharing sensitive information, make sure youre on a federal We would like to send you the latest marketing information about our services and whats happening at KIMS Hospital. ; Sipe, T.A. Uterine Septum with or without Hysteroscopic Metroplasty: Impact on Fertility and Obstetrical OutcomesA Systematic Review and Meta-Analysis of Observational Research. Lead Clinician for the Gynaecological Oncology Service. Titles and/or abstracts of studies retrieved using the electronic search strategy and those from additional sources were screened independently by two review authors (GS, MM) to identify studies that potentially meet the inclusion criteria outlined above. Sugiura-Ogasawara, M.; Lin, B.L. The authors concluded that more research is needed to measure the effectiveness of the hysteroscopic treatment of suspected major uterine cavity abnormalities in women with unexplained subfertility [, A meta-analysis on this topic concluded that septum resection was associated with a lower rate of miscarriage compared with untreated women and no significant effect was seen on live birth, clinical pregnancy rate or preterm delivery [, More recently, a systematic review and meta-analysis comparing reproductive outcomes between women undergoing hysteroscopic resection of the uterine septum and those with expectant management supported that hysteroscopic metroplasty was effective in reducing the risk of miscarriage in patients with complete or partial uterine septum. We work with specialists that are experienced in treating common and complex gynaecological conditions and investigate and treat a full range of gynaecological cases, including: We work with private Consultants that are nationally and internationally renowned for their success and are accredited with the GMC in both general gynaecology and gynaecology surgery. 2022. WebView the profiles of people named Roberto Tozzi. Valle, R.F. interesting to readers, or important in the respective research area. This site needs JavaScript to work properly. 12 with electro-surgery. MRI: Magnetic Resonance Imaging. Patients found to have one or more uterine fibroids or polyps distorting the endometrial cavity. 55 procedures performed with a 21-Fr resectoscope. Our data are in line with two previously published systematic reviews of Venetis et al. In order to be human-readable, please install an RSS reader. The meta-regression analyses supply the information about the potential moderating effect of some characteristics on the observed effect sizes. Between 2009 and 2013 all operations were performed by the gynecologic oncology team alone (group 1). The rate of bowel diversion was 36.5% in group 1 vs. 46.3% in group 2 (p=0.26). WebOthers Named Roberto Tozzi. Conservative management of uterine adenosarcoma: lessons learned from 20years of follow-up. Join Facebook to connect with Roberto Tozzi and others you may know. Patients with chromosome abnormalities, unicornuate, bicornuate, didelphis uterus. Rigid hysteroscope with a 26 gauge resectoscope (Karl Storz). The quality assessment conducted for the purpose of this meta-analysis suggested that most of the studies were of average quality, with only three out of 25 studies being graded as of high quality. He is actively involved in teaching registrars/fellows and medical students from the University of Oxford. The septum was divided by the laser after exploration of the cavity. ; Fedele, L.; Zamberletti, D.; De Virgillis, D.; Carinelli, S. Endometrial patterns in malformed uteri. We use cookies on our website to ensure you get the best experience. ; Moratalla, E. Effect of Hysteroscopic Metroplasty on Reproductive Outcomes in Women with Septate Uterus: Systematic Review and Meta-Analysis. The electronic searches provided a total of 2390 citations: after the removal of 550 duplicate records, 1840 references remained. Results: Ann Surg Oncol. Tozzi R, Casarin J, Baysal A, Valenti G, Kilic Y, Majd HS, Morotti M. J Gynecol Oncol. Since 2013 the RSR was performed by the colorectal team together with the gynecologic oncologist (group 2). ; The PRISMA Group. In three studies reporting data from infertile patients, PR was not different in women with septate uterus vs. controls (OR 1.66, 95% CI 0.48 to 5.73; In four studies reporting data from recurrent abortion, PR was not different in women who had the uterine septum removed vs. not removed (OR 1.22, 95% CI 0.51 to 2.92; All six studies were judged to be of medium quality, thus the sensitivity analysis overlapped with the complete analysis [. In the sections Treated uterine septum versus controls (untreated septum) and Before and after septum removal clinical heterogeneity within and between studies represents a limit of this meta-analysis that is worth highlighting. , T. ; Kuchenbecker, W. ; Jansen, F.W features are unavailable. Rules in our COVID-19 section Moratalla, E. effect of some characteristics on the observed effect sizes Foundation for Computing! Society for Reproductive Medicine are in line with two previously published Systematic reviews of Venetis et al at... 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Be human-readable, please install an RSS reader distorting the endometrial cavity duplicate records, 1840 references.... ) [ general analysis respective Research area Hysteroscopic treatment of uterine septum national and international clinical including!
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